Seeing the herpesvirus capsid at 8.5 A.
Science
; 288(5467): 877-80, 2000 May 05.
Article
de En
| MEDLINE
| ID: mdl-10797014
ABSTRACT
Human herpesviruses are large and structurally complex viruses that cause a variety of diseases. The three-dimensional structure of the herpesvirus capsid has been determined at 8.5 angstrom resolution by electron cryomicroscopy. More than 30 putative alpha helices were identified in the four proteins that make up the 0.2 billion-dalton shell. Some of these helices are located at domains that undergo conformational changes during capsid assembly and DNA packaging. The unique spatial arrangement of the heterotrimer at the local threefold positions accounts for the asymmetric interactions with adjacent capsid components and the unusual co-dependent folding of its subunits.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Capside
/
Herpèsvirus humain de type 1
Langue:
En
Journal:
Science
Année:
2000
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique