Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit.
Neuron
; 26(1): 81-91, 2000 Apr.
Article
de En
| MEDLINE
| ID: mdl-10798394
ABSTRACT
Axons of olfactory sensory neurons expressing a given odorant receptor converge to a few glomeruli in the olfactory bulb. We have generated mice with unresponsive olfactory sensory neurons by targeted mutagenesis of a cyclic nucleotide-gated channel subunit gene, OCNC1. When these anosmic mice were crossed with mice in which neurons expressing a given odorant receptor can be visualized by coexpression of an axonal marker, the pattern of convergence was affected for one but not another receptor. In a novel paradigm, termed monoallelic deprivation, axons from channel positive or negative neurons that express the same odorant receptor segregate into distinct glomeruli within the same bulb. Thus, the peripheral olfactory projections are in part influenced by mechanisms that depend on neuronal activity.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Bulbe olfactif
/
Axones
/
Mutagenèse
/
Neurorécepteurs olfactifs
/
Canaux ioniques
Limites:
Animals
Langue:
En
Journal:
Neuron
Sujet du journal:
NEUROLOGIA
Année:
2000
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique