Heuristic comparison of sertraline with nortriptyline for the treatment of depression in frail elderly patients.
Am J Geriatr Psychiatry
; 8(2): 141-9, 2000.
Article
de En
| MEDLINE
| ID: mdl-10804075
ABSTRACT
Studies have demonstrated that the selective serotonin reuptake inhibitor antidepressants have similar efficacy to other agents, such as tricyclic antidepressants. However, data are limited for direct comparisons with other antidepressants. The authors conducted a contemporaneous comparison of nursing home residents treated with open-label sertraline in doses up to 100 mg/day with nursing home residents treated in a double-blind randomized study of low vs. regular doses of nortriptyline. There were 97 patients enrolled in the study (28 treated with sertraline), with an average treatment duration of 55 days. There were no differences in the tolerability of sertraline vs. nortriptyline. However, in this group of frail older adults, sertraline was not as effective as nortriptyline for the treatment of depression.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Personne âgée fragile
/
Sertraline
/
Trouble dépressif
/
Antidépresseurs
/
Nortriptyline
Type d'étude:
Clinical_trials
/
Diagnostic_studies
Limites:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Am J Geriatr Psychiatry
Sujet du journal:
GERIATRIA
/
PSIQUIATRIA
Année:
2000
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique