Clinical and haemodynamic aspects of hepatopulmonary syndrome in Indian patients with cirrhosis.
J Gastroenterol Hepatol
; 15(4): 412-6, 2000 Apr.
Article
de En
| MEDLINE
| ID: mdl-10824886
ABSTRACT
BACKGROUND:
Hepatopulmonary syndrome consists of the triad of hepatic dysfunction and/or portal hypertension, intrapulmonary vascular dilatation and hypoxaemia, in the absence of detectable primary cardiopulmonary diseases. In the present study, we examined the frequency of hepatopulmonary syndrome among Indian patients with cirrhosis, and studied clinical predictors and pulmonary haemodynamic alterations.METHODS:
Forty-five patients with cirrhosis and no cardiopulmonary diseases were investigated by air-contrast echocardiography. Where patients were positive, arterial blood gas analysis was carried out. Positive contrast echocardiography with PO2 < 70 mmHg confirmed the diagnosis of hepatopulmonary syndrome. Three cases with the syndrome and 24 without were assessed for haemodynamic status by hepatic and pulmonary catheterization.RESULTS:
Four of 45 cases of cirrhosis (8.9%) had positive contrast echocardiographies, including three (6.7%) with hepatopulmonary syndrome and one 'subclinical' case (positive contrast echocardiography without hypoxaemia). Under haemodynamic study, the mean pulmonary arterial and pulmonary capillary wedge pressures appeared to be lower among those patients with hepatopulmonary syndrome.CONCLUSIONS:
In this small study, the frequency of hepatopulmonary syndrome was relatively low (6.7%). Cyanosis was the only reliable clinical indicator, and there was no clear relationship with the severity of cirrhosis by Child's grading.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Syndrome hépatopulmonaire
/
Hémodynamique
/
Cirrhose du foie
Type d'étude:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
J Gastroenterol Hepatol
Sujet du journal:
GASTROENTEROLOGIA
Année:
2000
Type de document:
Article
Pays d'affiliation:
Inde