Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists.
Bioorg Med Chem Lett
; 10(10): 1109-11, 2000 May 15.
Article
de En
| MEDLINE
| ID: mdl-10843229
ABSTRACT
A series of 4-diarylaminotropanes has been prepared. Both endo and exo diastereomeric forms bound to the delta opioid receptor but the endo isomers were more potent and selective versus the mu opioid receptor than the exo isomers. The most potent delta opioid agonist (14) exhibited a delta opioid Ki of 0.2 nM and was 860-fold selective over mu.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tropanes
/
Récepteur delta
/
Diphénylamine
Limites:
Animals
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2000
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique