YAC/BAC-based physical and transcript mapping around the gracile axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and Hip2 genes.
Genomics
; 66(3): 333-6, 2000 Jun 15.
Article
de En
| MEDLINE
| ID: mdl-10873389
ABSTRACT
We generated a yeast artificial chromosome (YAC)/bacterial artificial chromosome (BAC)-based physical and transcript map of a region containing the gracile axonal dystrophy (gad) locus on mouse chromosome 5. The YAC/BAC contig consists of 13 YAC and 49 BAC clones onto which 4 genes, 40 expressed sequence tags, and 7 new DNA polymorphisms were ordered. Using this physical map, we mapped Uchl1 encoding ubiquitin carboxyl-terminal hydrolase I, whose deletion has been determined to cause the gad mutation. We also mapped three other recently identified genes Hip2, encoding Huntingtin interacting protein 2; Atp3a2, encoding a P-type ATPase; and Pmx2b, encoding PHOX2b.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Facteurs de transcription
/
Chromosomes artificiels de levure
/
Dystrophies neuroaxonales
/
Cartographie physique de chromosome
/
Cartographie de contigs
/
Ubiquitin-conjugating enzymes
/
Protéines de transfert des phospholipides
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Genomics
Sujet du journal:
GENETICA
Année:
2000
Type de document:
Article
Pays d'affiliation:
Japon