Nocturnal hypoventilation in chronic respiratory failure (CRF) due to neuromuscular disease.
Sleep
; 23 Suppl 4: S204-8, 2000 Jun 15.
Article
de En
| MEDLINE
| ID: mdl-10893104
ABSTRACT
Decrease of respiratory muscle capacities in neuromuscular disease can lead to chronic respiratory failure with permanent alveolar hypoventilation. Respiratory centers elaborate a strategy of breathing dedicated to prevent overt respiratory muscles fatigue. This strategy may worsen chronic hypercapnia. During sleep, ventilation decreases because a lessening in respiratory centers function. During NREM sleep hypoventilation is only an exacerbation of what is seen during wakefulness. During REM sleep, atonia worsens much more hypoventilation particularly when diaphragmatic function is impaired. The effects of atonia are amplified by a very low reactivity of respiratory centers. Nocturnal mechanical ventilation improves nocturnal hypoventilation and daytime arterial blood gases (ABG). Mechanism of improvement in ABG and how nocturnal hypoventilation and diurnal hypoventilation interact, are still a matter of debate.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Insuffisance respiratoire
/
Hypoventilation
/
Maladies neuromusculaires
Type d'étude:
Diagnostic_studies
Limites:
Humans
Langue:
En
Journal:
Sleep
Année:
2000
Type de document:
Article
Pays d'affiliation:
France