Comparison of simultaneously measured perfusion and BOLD signal increases during brain activation with T(1)-based tissue identification.
Magn Reson Med
; 44(1): 137-43, 2000 Jul.
Article
de En
| MEDLINE
| ID: mdl-10893532
ABSTRACT
Perfusion and blood oxygenation level-dependent (BOLD) signals were simultaneously measured during a finger-tapping task at 3T using QUIPSS II with thin-slice TI(1) periodic saturation, a modified pulsed arterial spin labeling technique that provides quantitative measurement of perfusion. Perfusion and BOLD signal changes due to motor activation were obtained and correlated with the T(1) values estimated from echo-planar imaging (EPI)-based T(1) maps on a voxel-by-voxel basis. The peak perfusion signal occurs in voxels with a T(1) of brain parenchyma while the peak BOLD signal occurs in voxels with a T(1) characteristic of blood and cerebrospinal fluid. The locations of the peak signals of functional BOLD and perfusion only partially overlap on the order of 40%. Perfusion activation maps will likely represent the sites of neuronal activity better than do BOLD activation maps. Magn Reson Med 44137-143, 2000.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Encéphale
/
Imagerie par résonance magnétique
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Magn Reson Med
Sujet du journal:
DIAGNOSTICO POR IMAGEM
Année:
2000
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique