Review article: gall-bladder motor function in diabetes mellitus.
Aliment Pharmacol Ther
; 14 Suppl 2: 62-5, 2000 May.
Article
de En
| MEDLINE
| ID: mdl-10903007
ABSTRACT
Although some controversy exists, diabetic patients generally are thought to have a two- to threefold increased risk of cholesterol gallstones. From previous studies there is no convincing evidence for a supersaturated bile in diabetics, whereas several reports indicate that impaired gall-bladder emptying could be one of the important factors in the increased incidence of gallstones in diabetics. However, studies of gall-bladder motility in diabetics have yielded conflicting results, probably because of substantial heterogeneity in the patients studied, emptying stimulus and technique used to assess gall-bladder motor function. The mechanism of the gall-bladder emptying abnormality in diabetics is not completely understood, although it has been proposed that it could represent a manifestation of denervation caused by visceral neuropathy. Based on normal post-prandial cholecystokinin release, it can be ruled out that impaired cholecystokinin release is the mechanism responsible for reduced gall-bladder emptying in diabetics. Other possible explanations for impaired gall-bladder contraction in diabetics include a decreased sensitivity of the smooth muscle of the gall-bladder to plasma cholecystokinin, and/or decreased cholecystokinin receptors on the gall-bladder wall.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lithiase biliaire
/
Diabète
/
Vésicule biliaire
/
Motilité gastrointestinale
Type d'étude:
Etiology_studies
Limites:
Humans
Langue:
En
Journal:
Aliment Pharmacol Ther
Sujet du journal:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Année:
2000
Type de document:
Article
Pays d'affiliation:
Italie