Reversible tacrolimus-induced neurotoxicity isolated to the brain stem.
AJNR Am J Neuroradiol
; 21(7): 1251-4, 2000 Aug.
Article
de En
| MEDLINE
| ID: mdl-10954277
ABSTRACT
Diplopia, nystagmus, visual hallucinations, and internuclear ophthalmoplegia developed in a 30-year-old woman 84 days after she received a matched, unrelated bone marrow transplant for chronic myeloid leukemia. A regimen of tacrolimus had been administered since the transplantation was performed. MR imaging revealed bilaterally symmetric regions of signal abnormality with abnormal contrast enhancement in the brain stem. No supratentorial abnormality was present. Tacrolimus therapy was discontinued, and the symptoms resolved. MR imaging that was performed 10 days after tacrolimus was discontinued showed resolution of the abnormalities.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tronc cérébral
/
Imagerie par résonance magnétique
/
Leucémie myéloïde chronique BCR-ABL positive
/
Transplantation de moelle osseuse
/
Tacrolimus
/
Syndromes neurotoxiques
/
Immunosuppresseurs
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limites:
Adult
/
Female
/
Humans
Langue:
En
Journal:
AJNR Am J Neuroradiol
Année:
2000
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique