Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors.

Egbertson, M S; Bednar, B; Askew, B C; Bednar, R A; Brashear, K; Breslin, M J; Duggan, M E; Fisher, T E; Halczenko, W; Hutchinson, J H; Ihle, N; Prugh, J D; Wai, J S; Gould, R J; Hartman, G D

Egbertson, M S; Bednar, B; Askew, B C; Bednar, R A; Brashear, K; Breslin, M J; Duggan, M E; Fisher, T E; Halczenko, W; Hutchinson, J H; Ihle, N; Prugh, J D; Wai, J S; Gould, R J; Hartman, G D.

Affiliation

Egbertson MS; Merck Research Laboratories, Department of Medicinal Chemistry, West Point, PA 19486, USA. melissa_egbertson@merck.com

Bioorg Med Chem Lett ; 10(17): 1943-8, 2000 Sep 04.

Article de En | MEDLINE | ID: mdl-10987423

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Collection: 01-internacional Base de données: MEDLINE Sujet principal: Complexe glycoprotéique IIb-IIIa de la membrane plaquettaire Limites: Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2000 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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