Localization of a blood pressure QTL on rat chromosome 1 using Dahl rat congenic strains.
Physiol Genomics
; 1(3): 119-25, 1999 Nov 11.
Article
de En
| MEDLINE
| ID: mdl-11015570
ABSTRACT
We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F(2) population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic strain introgressing a large 118-centimorgan (cM) segment of LEW chromosome 1 into the S background had been constructed. This initial congenic strain had a reduced blood pressure compared with S rats, proving the existence of a blood pressure QTL, but not giving a good localization of the QTL. In the present work a series of five overlapping congenic substrains were produced from the original congenic strain in order to localize a blood pressure QTL to a 25-cM region near the center of chromosome 1. The congenic substrains also ruled out the Sa locus as a blood pressure QTL in the S vs. LEW comparison because the Sa locus was contained in a congenic substrain that did not alter blood pressure.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pression sanguine
/
Chromosomes
/
Caractère quantitatif héréditaire
Limites:
Animals
Langue:
En
Journal:
Physiol Genomics
Sujet du journal:
BIOLOGIA MOLECULAR
Année:
1999
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique