[IgD myeloma manifesting as acute renal insufficiency]. / Myélome à IgD révélé par une insuffisance rénale aiguë.
Rev Med Interne
; 21(9): 799-803, 2000 Sep.
Article
de Fr
| MEDLINE
| ID: mdl-11039177
ABSTRACT
INTRODUCTION:
IgD myeloma is a rare disease, comprising only 1-2% of all cases of myeloma. EXEGESIS A 71-year-old woman was admitted with acute renal failure, hypercalcemia and IgD lambda multiple myeloma. Dialysis was necessary. Six monthly cures of chemotherapy of induction according to the protocol VAD (vincristine, doxorubicin and dexamethasone) allowed to achieve moderate chronic renal failure (serum creatinine = 120 mumol/L). Sixteen months later, the patient developed an abdominal mass due to an IgD plasmocytoma in spite of treatment with interferon alpha and dexamethasone. Chemotherapy with melphalan and dexamethasone allowed to the disappearance of plasmocytoma and remission. The death occurred 36 months after the diagnosis.CONCLUSION:
This observation allows to display the particularities of IgD myeloma remarkable preponderance of lambda-type light chains, small or no visible monoclonal spike on serum electrophoresis, frequent extraosseous spread of tumor, renal failure and presence of osteolytic lesions. Over the last years, management and prediction of the survival time of IgD myeloma patients have improved.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Immunoglobuline D
/
Atteinte rénale aigüe
/
Hypercalcémie
/
Myélome multiple
Type d'étude:
Guideline
/
Prognostic_studies
Limites:
Aged
/
Female
/
Humans
Langue:
Fr
Journal:
Rev Med Interne
Année:
2000
Type de document:
Article
Pays d'affiliation:
France