Homologous and heterologous Borrelia burgdorferi challenge of infection-derived immune rabbits using host-adapted organisms.
Infect Immun
; 69(1): 593-8, 2001 Jan.
Article
de En
| MEDLINE
| ID: mdl-11119560
ABSTRACT
We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (>10(6)) of host-adapted Borrelia burgdorferi (HAB) (E. S. Shang, C. I. Champion, X. Wu, J. T. Skare, D. B. Blanco, J. N. Miller, and M. A. Lovett, Infect. Immun. 684189-4199, 2000). In this study, we have extended these findings to determine whether B31 strain infection-immune rabbits are also protected against heterologous HAB challenge. Infection-immune rabbits challenged with large numbers (>10(6)) of homologous HAB strain B31 were completely protected from erythema migrans (EM) and skin and disseminated infection. In contrast, infection-immune rabbits challenged with heterologous HAB strains N40 and Sh-2-82 were completely susceptible to EM and skin and disseminated infection; challenge with strain 297 also resulted in EM and infection of the skin and viscera, but clearance of infection occurred 3 weeks postchallenge. These findings confirm that immunity elicited in rabbits by B31 strain infection confers complete protection against large-dose homologous HAB challenge but not against a heterologous strain.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines de la membrane externe bactérienne
/
Maladie de Lyme
/
Vaccins contre la maladie de Lyme
/
Lipoprotéines
/
Antigènes de surface
Limites:
Animals
Langue:
En
Journal:
Infect Immun
Année:
2001
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique