Differences in DNA packaging genes and sensitivity to benzimidazole ribonucleosides between human cytomegalovirus strains AD169 and Towne.
Antivir Chem Chemother
; 11(5): 349-52, 2000 Sep.
Article
de En
| MEDLINE
| ID: mdl-11142634
ABSTRACT
The AD169 strain of human cytomegalovirus was approximately twofold more sensitive to polyhalogenated benzimidazole ribonucleosides than Towne strain. Sequence differences between the two strains have been identified in genes UL51, UL52, UL56, UL77, UL89 and UL104. Because these genes are involved in cleavage and packaging of viral DNA and the benzimidazole ribonucleosides inhibit this process, these sequence differences may be involved in the difference in drug sensitivity.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ribonucléosides
/
Benzimidazoles
/
Assemblage viral
/
Cytomegalovirus
Type d'étude:
Diagnostic_studies
Langue:
En
Journal:
Antivir Chem Chemother
Sujet du journal:
QUIMICA
/
TERAPIA POR MEDICAMENTOS
/
VIROLOGIA
Année:
2000
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique