Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition.
Nat Immunol
; 2(2): 145-9, 2001 Feb.
Article
de En
| MEDLINE
| ID: mdl-11175812
ABSTRACT
We examined the role of a cytosolic phospholipase A2 (cPLA2) in antigen-induced eosinophil infiltration of airways and in airway hyperresponsiveness to methacholine. Inhibition of cPLA2, or blockade of the platelet-activating factor (PAF) receptor, blocked antigen-induced airway hyperresponsiveness and suppressed eosinophil infiltration. Neither cyclooxygenase nor 5-lipoxygenase inhibition had either effect. We show here that, in antigen-sensitized guinea pigs, cPLA2 inhibition prevents both eosinophilic infiltration and subsequent airway hyperresponsiveness after antigen challenge. We also show that this effect is mediated by first-step hydrolysis of membrane phospholipid into lysophospholipid rather than by prostanoid or leukotriene metabolites of arachidonate.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Phospholipases A
/
Hypersensibilité respiratoire
/
Acide eicosapentanoïque
/
Granulocytes éosinophiles
Limites:
Animals
Langue:
En
Journal:
Nat Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2001
Type de document:
Article
Pays d'affiliation:
Japon