Cytological grading of breast cancer in Giemsa-stained fine needle aspiration smears.
Cytopathology
; 12(1): 15-25, 2001 Feb.
Article
de En
| MEDLINE
| ID: mdl-11256933
ABSTRACT
A potential cytological nuclear grading based on a semi-quantitative evaluation of three basic nuclear features, size of cell nuclei, anisonucleosis and the proportion of nucleoli-containing-nuclei, was tested on 74 Giemsa-stained fine needle aspiration of breast smears for its reliability in establishing the malignant potential of breast cancer. The prognostic impact of DNA-ploidy and S-phase fraction was also assessed. A good correlation between the three basic nuclear features, DNA-ploidy, S-phase fraction, cytological nuclear grade and histological grade, was shown. Using the cytological nuclear grade proposed, correct classification of cases between low histological grade (HG I) and high histological grade (HG II + HG III) was achieved in 79.73%. A statistically significant difference in 5-year survival rate was also observed between low malignancy grade and high malignancy grade breast cancer patients, regardless of the grading method used. DNA-ploidy and S-phase fraction were not statistically significant in establishing the malignant potential of breast cancer.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du sein
/
Carcinome canalaire du sein
Type d'étude:
Prognostic_studies
Limites:
Female
/
Humans
Langue:
En
Journal:
Cytopathology
Sujet du journal:
PATOLOGIA
Année:
2001
Type de document:
Article
Pays d'affiliation:
Slovénie