The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered.
Behav Pharmacol
; 12(1): 1-11, 2001 Feb.
Article
de En
| MEDLINE
| ID: mdl-11270507
ABSTRACT
Growing attention has been directed towards the potential involvement of the dopamine D3 receptor (D3R) in modulating effects of psychomotor stimulants. BP 897 (N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthylcarboxamide; aka BP 4.897 and DO897) is amongst the most selective partial agonists for the D3R receptor thus far reported. BP 897 was tested for its ability to support self-administration in rhesus monkeys (0.3-30 microg/kg) and for its ability to produce cocaine- and D-amphetamine-like discriminative stimulus effects in mice (0.01-17 mg/kg i.p.). BP 897 was not self-administered above vehicle and saline levels in any of the four monkeys tested, and produced less than 30% generalization from either the cocaine or D-amphetamine stimulus. When BP 897 was administered before administrations of cocaine or D-amphetamine, percent drug-lever selections were reduced. These results suggest that BP 897 has a profile of activity suitable for consideration as a potential treatment for cocaine dependency disorders.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pipérazines
/
Récepteur D2 de la dopamine
/
Cocaïne
/
Inhibiteurs de la capture de la dopamine
/
Agonistes de la dopamine
/
Troubles liés à une substance
/
Dexamfétamine
/
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Behav Pharmacol
Sujet du journal:
CIENCIAS DO COMPORTAMENTO
/
FARMACOLOGIA
Année:
2001
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique