Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin.
Bioorg Med Chem Lett
; 11(6): 769-72, 2001 Mar 26.
Article
de En
| MEDLINE
| ID: mdl-11277516
ABSTRACT
The design and synthesis of the lipophilic (9) and fluorescent (10) conjugates of a structural analogue of distamycin and their in vitro cellular localization studies are reported. Confocal laser scanning microscopy (CLSM) indicates that 10 rapidly enters human ovarian adenocarcinoma (SKOV-3) cells with principal uptake in mitochondria and uniform cytoplasmic distribution.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Nylons
Limites:
Female
/
Humans
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2001
Type de document:
Article
Pays d'affiliation:
Canada