Low-threshold N-methyl-D-aspartate receptor function correlates negatively with learning.
Brain Res
; 900(1): 38-47, 2001 May 04.
Article
de En
| MEDLINE
| ID: mdl-11325344
ABSTRACT
The intermediate, medial hyperstriatum ventrale (IMHV) is an area of the forebrain of the domestic chick which exhibits great plasticity. Moreover, there is a strong link between plasticity in the IMHV and specific changes in behaviour. The IMHV in vitro is still plastic, and many of its physiological properties are age-dependent, peaking in slices taken from 3- or 4-day-old birds. This 'window' coincides with an important transitional period in a chick's normal behavioural development. It has also been claimed that reversal training is at its most effective in 3- and 4-day-old birds - a proposition which was confirmed by the experiments reported here. A combination of in vivo training followed by in vitro electrophysiology also revealed that the function of low-threshold N-methyl-D-aspartate receptors (one of the age-related variables) is negatively related to the effectiveness of reversal training, when age is held constant.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Noyaux gris centraux
/
Poulets
/
Récepteurs du N-méthyl-D-aspartate
/
Apprentissage
/
Protéines de tissu nerveux
/
Plasticité neuronale
Limites:
Animals
Langue:
En
Journal:
Brain Res
Année:
2001
Type de document:
Article
Pays d'affiliation:
Royaume-Uni