Fractalkine, a CX3C-chemokine, functions predominantly as an adhesion molecule in monocytic cell line THP-1.
Immunol Cell Biol
; 79(3): 298-302, 2001 Jun.
Article
de En
| MEDLINE
| ID: mdl-11380684
ABSTRACT
A newly identified CX3C-chemokine, fractalkine, expressed on activated endothelial cells plays an important role in leucocyte adhesion and migration. Co-immobilized fractalkine with fibronectin or intercellular adhesion molecule-1 enhanced adhesion of THP-1 cells, which express the fractalkine receptor (CX3CR1), compared with that observed for each alone. That adherence was fractalkine-dependent and was confirmed in blocking studies. However, soluble fractalkine induced little chemotaxis in THP-1 cells in comparison to monocyte chemotactic protein-1 (MCP-1), which induced a strong chemotactic response. Moreover, the membrane form of fractalkine expressed on ECV304 cells reduced MCP-1 mediated chemotaxis of THP-1 cells. These results indicate that fractalkine may function as an adhesion molecule between monocytes and endothelial cells rather than as a chemotactic factor.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Monocytes
/
Molécules d'adhérence cellulaire
/
Adhérence cellulaire
/
Chimiokines CX3C
/
Protéines membranaires
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Immunol Cell Biol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2001
Type de document:
Article
Pays d'affiliation:
Japon