Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome.
Emerg Infect Dis
; 7(3): 375-81, 2001.
Article
de En
| MEDLINE
| ID: mdl-11384512
ABSTRACT
Unique clinical characteristics and other variables influencing the outcome of Cryptococcus neoformans infection in organ transplant recipients have not been well defined. From a review of published reports, we found that C. neoformans infection was documented in 2.8% of organ transplant recipients (overall death rate 42%). The type of primary immunosuppressive agent used in transplantation influenced the predominant clinical manifestation of cryptococcosis. Patients receiving tacrolimus were significantly less likely to have central nervous system involvement (78% versus 11%, p =0.001) and more likely to have skin, soft-tissue, and osteoarticular involvement (66% versus 21%, p = 0.006) than patients receiving nontacrolimus- based immunosuppression. Renal failure at admission was the only independently significant predictor of death in these patients (odds ratio 16.4, 95% CI 1.9-143, p = 0.004). Hypotheses based on these data may elucidate the pathogenesis and may ultimately guide the management of C. neoformans infection in organ transplant recipients.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Transplantation d'organe
/
Cryptococcose
Type d'étude:
Prognostic_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Emerg Infect Dis
Sujet du journal:
DOENCAS TRANSMISSIVEIS
Année:
2001
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique