Evaluation of anti-Schistosoma mansoni IgG antibodies in patients with chronic schistosomiasis mansoni before and after specific treatment.
Rev Inst Med Trop Sao Paulo
; 43(3): 153-9, 2001.
Article
de En
| MEDLINE
| ID: mdl-11452324
ABSTRACT
The circumoval precipitin test (COPT), enzyme-linked immunosorbent assay (ELISA) and the immunoblotting anti-adult worm antigen (AWA) and soluble egg antigen (SEA) tests were applied to 17 chronically schistosome-infected patients for the detection of anti-Schistosoma mansoni antibodies before and on four occasions after oxamniquine administration over a period of six months. Compared to a control group, schistosomiasis patients showed high levels of IgG antibodies in AWA and SEA-ELISA. A decrease in IgG levels was observed six months after treatment, although negative reactions were not obtained. Significant decreases in IgG1, IgG3 and, mainly, IgG4, but not anti-SEA IgG2 levels were observed six months after treatment, again without negativity. Analysis of anti-AWA IgG antibodies by immunoblotting before treatment showed a 31 kDa strand in 14 patients (82%) which disappeared in three cases up to six months after treatment; furthermore, anti-SEA IgG antibodies showed the same band in nine patients (53%) before treatment, which disappeared in only four cases up to six months after treatment.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Schistosoma mansoni
/
Schistosomiase à Schistosoma mansoni
/
Immunoglobuline G
/
Anticorps antihelminthe
Type d'étude:
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Rev Inst Med Trop Sao Paulo
Année:
2001
Type de document:
Article
Pays d'affiliation:
Brésil