In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells.
Braz J Med Biol Res
; 34(10): 1257-63, 2001 Oct.
Article
de En
| MEDLINE
| ID: mdl-11593299
ABSTRACT
Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors. LDE is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of LDL. We used LDE as a carrier for daunorubicin and assayed the cytotoxicity of the complex using AML blast cells since RT-PCR analysis showed that AML cells express LDL receptor mRNA. The LDEdaunorubicin complex killed 46.7% of blast cells and 20.2% of normal bone marrow cells (P<0.001; Student t-test). Moreover, this complex destroyed AML blast cells as efficiently as free daunorubicin. Thus, LDE might be a suitable carrier of chemotherapeutic agents targeting these drugs to neoplastic cells and protecting normal tissues.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Leucémie aigüe myéloïde
/
Daunorubicine
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Lipoprotéines LDL
/
Antibiotiques antinéoplasiques
Limites:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Braz J Med Biol Res
Année:
2001
Type de document:
Article
Pays d'affiliation:
Brésil