Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures.
J Immunol
; 167(10): 5543-7, 2001 Nov 15.
Article
de En
| MEDLINE
| ID: mdl-11698424
ABSTRACT
We studied recognition of the disease-associated HLA-B27 allele by immunomodulatory receptors encoded within the leukocyte receptor complex. HLA class I are ligands for members of the killer Ig receptor (KIR) and Ig-like transcript (ILT)/LIR/LILR families (the new LILR nomenclature is described at www. gene.ucl.ac.uk/nomenclature/genefamily/lilr.html). Members of these families bound HLA-B27 in both classical and beta(2) microglobulin-independent forms. Classical complexes bound ILT2, ILT4, and LIR6 transfectants but not ILT1, ILT3, or ILT5. A free H chain form of HLA-B27 bound ILT4 and LIR6. Both forms of HLA-B27 bound KIR3DL1 transfectants. HLA-B27 free H chain bound CD14(+) cells in PBL from healthy controls, consistent with ILT4 expression on monocytes. Alternative recognition of different forms of HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply a role in inflammatory disease.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Récepteurs immunologiques
/
Antigène HLA-B27
Limites:
Humans
Langue:
En
Journal:
J Immunol
Année:
2001
Type de document:
Article
Pays d'affiliation:
Royaume-Uni