2-Aryl-2,2-difluoroacetamide FKBP12 ligands: synthesis and X-ray structural studies.
Org Lett
; 3(25): 3987-90, 2001 Dec 13.
Article
de En
| MEDLINE
| ID: mdl-11735566
ABSTRACT
[structure see text] 2-Aryl-2,2-difluoroacetamido-proline and pipecolate esters are high affinity FKBP12 ligands whose rotamase inhibitory activity is comparable to that seen for the corresponding ketoamides. X-ray structural studies suggest that the fluorine atoms participate in discrete interactions with the Phe36 phenyl ring and the Tyr26 hydroxyl group, with the latter resembling a moderate-to-weak hydrogen bond.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tacrolimus
/
Protéine 1A de liaison au tacrolimus
/
Hydrocarbures fluorés
/
Acétamides
Limites:
Animals
Langue:
En
Journal:
Org Lett
Sujet du journal:
BIOQUIMICA
Année:
2001
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique