Increased serum interferon alpha in HIV-1 associated lipodystrophy syndrome.
Eur J Clin Invest
; 32(1): 43-50, 2002 Jan.
Article
de En
| MEDLINE
| ID: mdl-11851726
ABSTRACT
BACKGROUND:
A syndrome of lipodystrophy (LD) associated with peripheral lipoatrophy and central/visceral adiposity has been reported in HIV-1-infected patients treated by combined antiretroviral therapy (ART). Lipid metabolism is partly regulated by both steroid hormones and cytokines and we have previously reported that dyslipidaemia in LD-positive men is correlated to an increase in cortisol DHEA ratio (Christeff et al., AIDS 1999;132251). In this study we questioned whether it is also related to cytokine perturbations. MATERIALS ANDMETHODS:
A cross-sectional study was performed on 42 HIV-1-positive men on ART, 27 of whom had symptoms of LD, defined by computed tomography scan. Serum cytokines (IFN-alpha, TNF-alpha, sTNF-RI, sTNF-RII, IL-6, IL-1beta and IL-2) and lipids [cholesterol, triglycerides (TG) and their subclasses], and apolipoproteins (Apo), were determined.RESULTS:
Serum IFN-alpha was markedly increased in LD-positive compared with LD-negative men and controls. IL-6 and TNF-alpha concentrations were also significantly elevated in HIV-positive men compared to controls but the levels of these cytokines did not differ between the two groups of patients. A significant positive correlation was found between accumulation of IFN-alpha and increased levels of cholesterol, TG, VLDL cholesterol, VLDL TG, ApoB and ApoB-ApoA1 ratio. A multivariate forward-performed analysis revealed that IFN-alpha is the best marker for lipid perturbations associated to LD, followed by insulin and cortisol DHEA ratio.CONCLUSIONS:
This study demonstrates an association between serum IFN-alpha and lipid alterations in LD-positive men. The concomittant action of IFN-alpha and cortisol DHEA ratio is probably one of the mechanisms responsible for hyperlipidaemia in LD syndrome.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Syndrome d'immunodéficience acquise
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Interféron alpha
/
Lipodystrophie
Type d'étude:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limites:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Eur J Clin Invest
Année:
2002
Type de document:
Article
Pays d'affiliation:
France