Intravenous allicin improves pulmonary blood flow after ischemia-reperfusion injury in rats.
J Cardiovasc Surg (Torino)
; 43(2): 175-9, 2002 Apr.
Article
de En
| MEDLINE
| ID: mdl-11887050
ABSTRACT
BACKGROUND:
Allicin is a sulfur-containing compound extracted from garlic, with antiaggregatory, anti- migratory, anti-oxidant and pulmonary vasodilator actions. We hypothesized that allicin might be beneficial in lung ischemia-reperfusion.METHODS:
A non-nothermic rat lung ischemia-reperfusion model was established by clamping left pulmonary artery (PA) for 1 hr, followed by reperfusion for 2 hrs by clamping right PA to reflect solely the function of left lung. Groups were control (n=7), allicin 0.1 mg (n=8) and allicin 0.01 mg (n=4). In the beginning of reperfusion allicin/saline were injected. Pulmonary artery pressures (PAP), pulmonary artery flow (PAF), left atrial pressure (LAP) were monitored. At the end of reperfusion period arterial blood gas (ABG) analysis was done.RESULTS:
Six of 7 control and 3 of 8 group 2 animals died before completing the experiment. In group 1 all animals completed the experiment (p=0.015 vs control). PAF was significantly increased after 30, 60 and 120 min of reperfusion in group 1 (p=0.0028, 0.0009, 0.0003 respectively vs control) and after 60 and 120 minutes in group 2 (p=0.0453, 0.018 respectively vs control). Pulmonary vascular resistance was lower at 30 min in allicin 0.01 mg group (p=0.0017 vs control). PAP was increased after 60 and 120 min of reperfusion in group 1 (p=0.016, 0.0029 respectively vs control) and after 120 min in group 2 (p=0.0104 vs control).CONCLUSIONS:
This study shows that allicin improves postischemic PAF in this model. Allicin needs further investigation of potential utility and mechanism(s) of action.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acides sulfiniques
/
Vasodilatateurs
/
Antiagrégants plaquettaires
/
Lésion d'ischémie-reperfusion
/
Circulation pulmonaire
/
Antioxydants
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
J Cardiovasc Surg (Torino)
Année:
2002
Type de document:
Article
Pays d'affiliation:
Turquie