Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir).
Bioorg Med Chem Lett
; 12(8): 1185-7, 2002 Apr 22.
Article
de En
| MEDLINE
| ID: mdl-11934584
ABSTRACT
The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2' position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure-activity relationships explored.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pyrimidinones
/
Inhibiteurs de protéase du VIH
Limites:
Humans
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2002
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique