Synthesis and structure-activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir).

Sham, Hing L; Betebenner, David A; Chen, Xiaoqi; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J; Plattner, Jacob J; Norbeck, Daniel W

Sham, Hing L; Betebenner, David A; Chen, Xiaoqi; Saldivar, Ayda; Vasavanonda, Sudthida; Kempf, Dale J; Plattner, Jacob J; Norbeck, Daniel W.

Affiliation

Sham HL; Pharmaceutical Discovery, D47B, Building AP-10, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. hing.l.sham@abbott.com

Bioorg Med Chem Lett ; 12(8): 1185-7, 2002 Apr 22.

Article de En | MEDLINE | ID: mdl-11934584

ABSTRACT

ABSTRACT

The HIV protease inhibitor ABT-378 (Lopinavir) has a 2,6-dimethylphenoxyacetyl group in the P-2' position. Analogues in which this group is replaced with various substituted phenyl or heteroaryl groups were synthesized and the structure-activity relationships explored.

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Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrimidinones / Inhibiteurs de protéase du VIH Limites: Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2002 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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