Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.
Science
; 297(5579): 240-3, 2002 Jul 12.
Article
de En
| MEDLINE
| ID: mdl-12114623
ABSTRACT
Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone. To examine the mechanism underlying leptin's metabolic actions, we used transcription profiling to identify leptin-regulated genes in ob/ob liver. Leptin was found to specifically repress RNA levels and enzymatic activity of hepatic stearoyl-CoA desaturase-1 (SCD-1), which catalyzes the biosynthesis of monounsaturated fatty acids. Mice lacking SCD-1 were lean and hypermetabolic. ob/ob mice with mutations in SCD-1 were significantly less obese than ob/ob controls and had markedly increased energy expenditure. ob/ob mice with mutations in SCD-1 had histologically normal livers with significantly reduced triglyceride storage and VLDL (very low density lipoprotein) production. These findings suggest that down-regulation of SCD-1 is an important component of leptin's metabolic actions.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acyl-(acyl-carrier-protein)desaturase
/
Perte de poids
/
Leptine
/
Foie
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Science
Année:
2002
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique