A selective effect of Mpl ligand on mRNA stabilization during megakaryocyte differentiation.
FEBS Lett
; 527(1-3): 279-83, 2002 Sep 11.
Article
de En
| MEDLINE
| ID: mdl-12220674
ABSTRACT
Megakaryocytes, the platelet precursors, are induced to differentiate in response to Mpl ligand. Here we report that stability of the megakaryocyte-specific platelet factor 4 (PF4) mRNA is substantially augmented in the presence of Mpl ligand. This stabilization requires protein synthesis, but the 3'-untranslated region of PF4 mRNA is not sufficient for granting the effect. This cytokine also significantly or mildly stabilizes Mpl receptor or GAPDH mRNAs, respectively, in contrast to a previously reported lack of effect on P2Y(1) receptor mRNA. Our study is the first to suggest that Mpl ligand-induced lineage specification is also determined by message stabilization.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Thrombopoïétine
/
Facteur-4 plaquettaire
/
ARN messager
/
Mégacaryocytes
/
Stabilité de l'ARN
Limites:
Animals
Langue:
En
Journal:
FEBS Lett
Année:
2002
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique