Effects of short-chain fatty acid-supplemented total parenteral nutrition on intestinal pro-inflammatory cytokine abundance.
Dig Dis Sci
; 47(9): 2049-55, 2002 Sep.
Article
de En
| MEDLINE
| ID: mdl-12353854
ABSTRACT
We examined the effect of short-chain fatty acid-supplemented total parenteral nutrition on proinflammatory cytokine levels in piglets. Piglets (N = 22) received either standard total parenteral nutrition or total parenteral nutrition supplemented with short-chain fatty acids. After seven days of continuous nutrient infusion, proinflammatory cytokine (TNF-alpha, IL-1beta, IL-6) abundance in plasma, jejunal, and ileal samples and small intestinal myeloperoxidase was determined using western blotting. No differences were seen in TNF-alpha small intestinal abundance. IL-1beta was higher in the small intestine of the short-chain fatty acid group (P < 0.05). IL-6 was higher in intestinal samples of the short-chain fatty acid group (P = 0.05), with the ileum having a greater abundance of IL-6 than the jejunum (P < 0.005). No differences in proinflammatory cytokine abundance in the plasma or tissue myeloperoxidase were seen. These results indicate short-chain fatty acids beneficially increase small intestinal abundance of IL-1beta and IL-6 during total parenteral nutrition administration, while not affecting systemic production of these cytokines or intestinal inflammation.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Interleukine-6
/
Interleukine-1
/
Facteur de nécrose tumorale alpha
/
Nutrition parentérale totale
/
Acides gras volatils
/
Intestin grêle
Limites:
Animals
Langue:
En
Journal:
Dig Dis Sci
Année:
2002
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique