Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism.
Genes Immun
; 3(7): 436-9, 2002 Nov.
Article
de En
| MEDLINE
| ID: mdl-12424628
ABSTRACT
IL-13 is strongly implicated in the development of asthma and chronic obstructive pulmonary disease (COPD). We previously identified an IL-13 promoter polymorphism (-1055 C to T) that is associated with allergic asthma. We now report an increased frequency of the -1055 T allele in COPD patients compared to healthy controls (P=0.002) and compared to a second control group consisting of smoking individuals with normal lung function (P=0.01). A closely linked IL-13 exon polymorphism is present at normal allelic frequencies (P=0.3 and 0.4, respectively). In addition, we observed a normal distribution of two IL-4 polymorphisms at positions -590 and +33 (P=0.2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Régions promotrices (génétique)
/
Interleukine-13
/
Prédisposition génétique à une maladie
/
Broncho-pneumopathie chronique obstructive
Type d'étude:
Risk_factors_studies
Limites:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Genes Immun
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
BIOLOGIA MOLECULAR
Année:
2002
Type de document:
Article
Pays d'affiliation:
Pays-Bas