Effect of follow-up time on risk estimates: a longitudinal examination of the relative risks of leukemia and multiple myeloma in a rubber hydrochloride cohort.
Am J Ind Med
; 42(6): 481-9, 2002 Dec.
Article
de En
| MEDLINE
| ID: mdl-12439871
ABSTRACT
BACKGROUND:
Choice of follow-up time for an occupational cohort can influence risk estimates. We examined the effects of follow-up time on relative risk estimates for leukemia and multiple myeloma in a cohort of 1,845 rubber hydrochloride workers. MATERIALS ANDMETHODS:
We generated standardized mortality ratios (SMRs) for yearly follow-ups, beginning each study in 1940 and increasing study end dates from 1950 through 1996. We used Cox proportional hazards modeling to explore the effects of follow-up time on the exposure-response relationship.RESULTS:
The SMR for leukemia rose to 13.55 in 1961 and fell nearly monotonically to 2.47 by 1996. Cox modeling suggested interaction between cumulative exposure and time since exposure. A longer time to peak risk was seen for multiple myeloma.CONCLUSIONS:
Because summary risk estimates change with follow-up time, exposure limits set using these estimates may not adequately protect workers. Consideration of appropriate follow-up time and use of more complex temporal models are critical to the risk assessment process.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Benzène
/
Leucémies
/
Exposition professionnelle
/
Myélome multiple
/
Maladies professionnelles
Type d'étude:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Limites:
Humans
/
Male
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
Am J Ind Med
Année:
2002
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique