Lack of inhibition of endothelial nitric oxide synthase in the isolated rat aorta by doxorubicin.
Toxicol In Vitro
; 17(2): 165-7, 2003 Apr.
Article
de En
| MEDLINE
| ID: mdl-12650670
ABSTRACT
Besides inducing cardiotoxicity, doxorubicin also affects the vasculature. Recent observations in cultured endothelial cells indicated that the endothelial form of nitric oxide synthase might be inhibited by doxorubicin thereby seriously interfering with vascular function. We have investigated the effect of doxorubicin on the relaxation induced by the muscarinic agonist carbachol in the isolated rat aorta. It was found that doxorubicin at concentrations up to 50 microM does not alter the relaxant response to carbachol. Direct measurement of nitrite, the metabolite of NO*, by the Griess assay confirmed our observation that NO*)production is not inhibited by doxorubicin.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Endothélium vasculaire
/
Doxorubicine
/
Nitric oxide synthase
/
Antibiotiques antinéoplasiques
Limites:
Animals
Langue:
En
Journal:
Toxicol In Vitro
Sujet du journal:
TOXICOLOGIA
Année:
2003
Type de document:
Article
Pays d'affiliation:
Pays-Bas