A longitudinal neuropsychological study of partial brain radiation in adults with brain tumors.
Neurology
; 60(7): 1113-8, 2003 Apr 08.
Article
de En
| MEDLINE
| ID: mdl-12682316
ABSTRACT
OBJECTIVE:
To investigate longitudinal cognitive functioning in patients with brain tumor treated with modern highly conformal fractionated partial brain radiation therapy (RT).METHODS:
Seventeen (of 22 initial consecutive patients) adults with primarily low-grade brain neoplasms who underwent either biopsy or tumor resection were tested at pre-RT baseline and at 3, 6, 12, and 24 months after baseline. Participants were classified as RT-treated nonprogressors (n = 12) or progressors (n = 3) based on serial follow-up structural imaging. Two patients received surgery only and served as controls to help minimize surgical, practice, test form, or other potential non-RT effects. Serial neuropsychological assessments were conducted using alternate forms of the Selective Reminding Test, 10/36 Spatial Recall Test, and Symbol Digit Modality Test (oral, written) as well as the Shipley Scale (baseline only), Wechsler Adult Intelligence Scale-Revised Digit Span, Trail Making Test, and the Symptom Checklist-90-Revised Global Severity Index scale.RESULTS:
There was evidence of subtle attention and memory improvement in RT-treated nonprogressors throughout the 2-year period, with no evidence of cognitive decline. In contrast, patients with disease progression evidenced more substantial decline in memory and attention.CONCLUSIONS:
Partial brain fractionated RT was not associated with adverse neuropsychological effects through the first 2 years following therapy.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Encéphale
/
Tumeurs du cerveau
/
Fractionnement de la dose d'irradiation
/
Radiothérapie conformationnelle
/
Troubles de la mémoire
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limites:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Neurology
Année:
2003
Type de document:
Article
Pays d'affiliation:
Canada