[Nitric oxide donor increases the effectiveness of cytostatic therapy and inhibits the development of drug resistance]. / Donor oksida azota povyshaet éffektivnost' tsitostaticheskoi terapii i zaderzhivaet razvitie lekarstvennoi rezistentnosti.
Vopr Onkol
; 49(1): 71-5, 2003.
Article
de Ru
| MEDLINE
| ID: mdl-12715374
ABSTRACT
The investigation has established a potential of low-dosage chemotherapy with cytostatics when used in combination with nitric oxide (NO) donor. Such regimen resulted in more animals being cured of leukemias P388 and L1210 and longer survival. Similar effect was reported with transplantable intracerebral leukemia P388 in which case mean survival after cyclophosphamide plus NO-donor was three times as high as that after cyclophosphamide alone. Combination therapy also promoted animetastatic effect melanoma B16 inhibition by cyclophosphamide alone was 50% vs. 80% after cyclophosphamide plus NO-donor. NO-donor inhibited development of drug resistance to cyclophosphamide.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Mélanome expérimental
/
Leucémie P388
/
Protocoles de polychimiothérapie antinéoplasique
/
Antinéoplasiques alcoylants
/
Donneur d'oxyde nitrique
/
Cyclophosphamide
Limites:
Animals
/
Humans
Langue:
Ru
Journal:
Vopr Onkol
Année:
2003
Type de document:
Article