Inhibitory activities of three annonaceous acetogenins on NADH oxidase of chicken liver mitochondria.
Biol Pharm Bull
; 26(5): 729-32, 2003 May.
Article
de En
| MEDLINE
| ID: mdl-12736522
ABSTRACT
Annonaceous acetogenins (ACG) are natural products found in the plant family Annonaceae and which strongly inhibited mitochondrial complex I. The inhibition of NADH oxidase of chicken liver mitochondria by three different structural ACG was studied here, and ACG was shown to have potent inhibitory activities similar to rotenone for NADH oxidase. The IC(50) values indicated that bis-adjacent tetrahydrofuran (THF) type squamocin C was more potent than non-adjacent bis-THF type squamostatin B, and the latter was more potent than non-THF type compound 1 in the assay. The roles of structural factors of ACG such as the terminal gamma-lactone, the features of other ring moieties and hydroxyl groups, as well as the alkyl chain were simply discussed in this study.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
4-Butyrolactone
/
Mitochondries du foie
/
Annonaceae
/
Alcools gras
/
Lactones
/
Complexes multienzymatiques
/
NADH, NADPH oxidoreductases
Limites:
Animals
Langue:
En
Journal:
Biol Pharm Bull
Sujet du journal:
BIOQUIMICA
/
FARMACOLOGIA
Année:
2003
Type de document:
Article
Pays d'affiliation:
Chine