Association of TNF-alpha-857C with inflammatory bowel disease in the Australian population.
Scand J Gastroenterol
; 38(5): 533-4, 2003 May.
Article
de En
| MEDLINE
| ID: mdl-12795465
ABSTRACT
BACKGROUND:
It is now well established that susceptibility to inflammatory bowel disease is in part genetic, with one localization on chromosome 6 (IBD3) having been replicated in a number of populations. A candidate in that region, TNF-alpha, contains polymorphisms in the promoter region that appear to be associated with disease.METHODS:
More than 600 individuals from 170 multiplex IBD families were genotyped for four polymorphisms in the TNF-alpha gene and analysed for association. RESULTS ANDCONCLUSION:
A strong association was observed between transmission of the -857 C allele and disease. This effect was strongest in those families in which the NOD2 risk alleles are also segregating, supporting the existence of an interaction between IBD3 and IBD1 on chromosome 16.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies inflammatoires intestinales
/
Protéines de transport
/
Facteur de nécrose tumorale alpha
/
Protéines et peptides de signalisation intracellulaire
Type d'étude:
Risk_factors_studies
Limites:
Humans
Pays/Région comme sujet:
Oceania
Langue:
En
Journal:
Scand J Gastroenterol
Année:
2003
Type de document:
Article
Pays d'affiliation:
Australie