Measuring the effects of indomethacin on changes in cerebral oxidative metabolism and cerebral blood flow during sensorimotor activation.
Magn Reson Med
; 50(1): 99-106, 2003 Jul.
Article
de En
| MEDLINE
| ID: mdl-12815684
ABSTRACT
The work presented here uses combined blood oxygenation level-dependent (BOLD) and arterial spin tagging (AST) approaches to study the effect of indomethacin on cerebral blood flow (CBF) and oxygen consumption (CMRO(2)) increases during motor activation. While indomethacin reduced the CBF increase during activation, it did not significantly affect the CMRO(2) increase during activation. The ratio of the activation-induced CBF increase in the presence and absence of indomethacin was 0.54 +/- 0.08 (+/-SEM, n = 8, P < 0.001), while the ratio of the CMRO(2) increase in the presence and absence of the drug was 1.02 +/- 0.08 (+/-SEM, N = 8, ns). Potential difficulties in estimating CMRO(2) changes from combined BOLD/AST data are discussed.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cortex somatosensoriel
/
Imagerie par résonance magnétique
/
Indométacine
/
Activité motrice
/
Cortex moteur
Type d'étude:
Diagnostic_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Magn Reson Med
Sujet du journal:
DIAGNOSTICO POR IMAGEM
Année:
2003
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique