Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome.
Acta Crystallogr D Biol Crystallogr
; 59(Pt 7): 1294-5, 2003 Jul.
Article
de En
| MEDLINE
| ID: mdl-12832791
ABSTRACT
Gankyrin is an oncoprotein overexpressed in hepatocarcinoma cells that binds to the cell-cycle regulator CDK4 and the S6b ATPase subunit of the regulatory component of the proteasome. It belongs to the family of ankyrin-repeat proteins that appear to mediate protein-protein interactions in diverse biochemical processes. Gankyrin has been crystallized from polyethylene glycol solutions and diffraction data have been obtained from these crystals that extend to 2.1 A spacing.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines oncogènes
Limites:
Humans
Langue:
En
Journal:
Acta Crystallogr D Biol Crystallogr
Année:
2003
Type de document:
Article
Pays d'affiliation:
Royaume-Uni