Granulocyte macrophage colony stimulating factor (GM-CSF) activity is regulated by a GM-CSF binding molecule in Wallerian degeneration following injury to peripheral nerve axons.
J Neuroimmunol
; 140(1-2): 88-96, 2003 Jul.
Article
de En
| MEDLINE
| ID: mdl-12864975
ABSTRACT
The hematopoietic factor and inflammatory cytokine GM-CSF is involved in PNS and CNS injury and disease, and in macrophage and microglia function regulation. We presently document that injury to PNS axons induces in vivo production of GM-CSF-inhibitor and GM-CSF-augmenter activities. GM-CSF-inhibitor activity was detected in extract and conditioned medium (CM) of injured PNS but not in extract of intact PNS, and was removed from CM by GM-CSF affinity chromatography, suggesting it is carried by a secreted GM-CSF binding molecule. CM further displayed GM-CSF-augmenter activity along with GM-CSF-inhibitor activity but at contrasting concentrations; augmentation at lowest and inhibition at highest. GM-CSF activity is thus regulated during Wallerian degeneration (WD); augmenter activity characterizes the onset and inhibitor activity the later stages of WD.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Nerf ischiatique
/
Axones
/
Dégénérescence wallerienne
/
Protéines de transport
/
Facteur de stimulation des colonies de granulocytes et de macrophages
/
Récepteur de facteur de croissance granulocyte-macrophage
/
Récepteurs de surface cellulaire
Langue:
En
Journal:
J Neuroimmunol
Année:
2003
Type de document:
Article
Pays d'affiliation:
Israël