Inactivation of TNF signaling by rationally designed dominant-negative TNF variants.

Steed, Paul M; Tansey, Malú G; Zalevsky, Jonathan; Zhukovsky, Eugene A; Desjarlais, John R; Szymkowski, David E; Abbott, Christina; Carmichael, David; Chan, Cheryl; Cherry, Lisa; Cheung, Peter; Chirino, Arthur J; Chung, Hyo H; Doberstein, Stephen K; Eivazi, Araz; Filikov, Anton V; Gao, Sarah X; Hubert, René S; Hwang, Marian; Hyun, Linus; Kashi, Sandhya; Kim, Alice; Kim, Esther; Kung, James; Martinez, Sabrina P; Muchhal, Umesh S; Nguyen, Duc-Hanh T; O'Brien, Christopher; O'Keefe, Donald; Singer, Karen; Vafa, Omid; Vielmetter, Jost; Yoder, Sean C; Dahiyat, Bassil I

Steed, Paul M; Tansey, Malú G; Zalevsky, Jonathan; Zhukovsky, Eugene A; Desjarlais, John R; Szymkowski, David E; Abbott, Christina; Carmichael, David; Chan, Cheryl; Cherry, Lisa; Cheung, Peter; Chirino, Arthur J; Chung, Hyo H; Doberstein, Stephen K; Eivazi, Araz; Filikov, Anton V; Gao, Sarah X; Hubert, René S; Hwang, Marian; Hyun, Linus; Kashi, Sandhya; Kim, Alice; Kim, Esther; Kung, James; Martinez, Sabrina P; Muchhal, Umesh S; Nguyen, Duc-Hanh T; O'Brien, Christopher; O'Keefe, Donald; Singer, Karen; Vafa, Omid; Vielmetter, Jost; Yoder, Sean C; Dahiyat, Bassil I.

Affiliation

Steed PM; Xencor, 111 West Lemon Avenue, Monrovia, CA 91016, USA.

Science ; 301(5641): 1895-8, 2003 Sep 26.

Article de En | MEDLINE | ID: mdl-14512626

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Collection: 01-internacional Base de données: MEDLINE Sujet principal: Ingénierie des protéines / Transduction du signal / Facteur de nécrose tumorale alpha Type d'étude: Prognostic_studies Limites: Animals / Female / Humans Langue: En Journal: Science Année: 2003 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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