Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution.

Wendt, Michael D; Rockway, Todd W; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L

Wendt, Michael D; Rockway, Todd W; Geyer, Andrew; McClellan, William; Weitzberg, Moshe; Zhao, Xumiao; Mantei, Robert; Nienaber, Vicki L; Stewart, Kent; Klinghofer, Vered; Giranda, Vincent L.

Affiliation

Wendt MD; Cancer Research and Structural Biology, Global Pharmaceutical R & D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6101, USA. mike.d.wendt@abbott.com

J Med Chem ; 47(2): 303-24, 2004 Jan 15.

Article de En | MEDLINE | ID: mdl-14711304

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Collection: 01-internacional Base de données: MEDLINE Sujet principal: Activateur du plasminogène de type urokinase / Amidines / Naphtalènes Type d'étude: Diagnostic_studies Limites: Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2004 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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