Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease.
J Neurol Neurosurg Psychiatry
; 75(3): 478-80, 2004 Mar.
Article
de En
| MEDLINE
| ID: mdl-14966169
ABSTRACT
BACKGROUND:
The Saitohin gene has recently been identified in intron 9 of the Tau gene. Because an association between Parkinson's disease and Tau has been described, Saitohin represents a candidate gene for Parkinson's disease.OBJECTIVE:
To test these two genes for their association with Parkinson's disease in a large community based case-control study.RESULTS:
Cases (n = 208) were more often homozygotes for the Tau H1 haplotype than controls (n = 483; odds ratio (OR) = 1.71 (95% confidence interval, 1.20 to 2.43); p = 0.003), and the saitohin Q allele was in complete linkage disequilibrium with the H1 haplotype. This association was stronger among cases with Parkinson's disease onset below 65 years (< or =65 years OR = 2.52 (1.49 to 4.25); p<0.001) than among those with older onset (>65 years OR = 1.20 (0.73 to 1.98); p<0.47).CONCLUSIONS:
The data suggest that there is a functional polymorphism at this locus involved in Parkinson's disease.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladie de Parkinson
/
Polymorphisme génétique
/
Protéines tau
/
Prédisposition génétique à une maladie
Type d'étude:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Neurol Neurosurg Psychiatry
Année:
2004
Type de document:
Article
Pays d'affiliation:
France