Impact of the meningococcal C conjugate vaccine in Spain: an epidemiological and microbiological decision.
Euro Surveill
; 9(7): 11-5, 2004 Jul.
Article
de En
| MEDLINE
| ID: mdl-15318008
ABSTRACT
The new meningococcal C conjugate vaccine became available in Spain and was included in the infant vaccination schedule in 2000. A catch-up campaign was carried out in children under six years of age. As a consequence, the incidence of meningococcal disease caused by serogroup C has fallen sharply during the last three epidemiological years in Spain. The risk of contracting serogroup C disease in 2002/2003 fell by 58% when compared with the season before the conjugate vaccine was introduced. There was also an important decrease in mortality. Three deaths due to serogroup C occurred in the age groups targeted for vaccination in 2002/2003, compared with 30 deaths in the same age groups in the season before the launch of the vaccine campaign. In the catch-up campaign the vaccine coverage reached values above 92%. For the 2001, 2002 and 2003 routine childhood immunisation programme coverage values ranged from 90% to 95%. During the past three years a total of 111 cases of serogroup C disease have been reported in patients in the vaccine target group. Most of the vaccination failures occurred during the epidemiological year 2002/2003. Eight (53%) vaccine failures occurred in children who had been routinely immunised in infancy, and could be related to a lost of protection with time since vaccination. The isolation of several B2aP1.5 strains (ST-11 lineage) is noteworthy. These may have their origin in C2aP1.5 strains which, after undergoing genetic recombination at the capsular operon level, express serogroup B. These strains could have relevant epidemic potential.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vaccination de masse
/
Vaccination
/
Appréciation des risques
/
Vaccins antiméningococciques
/
Méningite à méningocoques
Type d'étude:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Euro Surveill
Sujet du journal:
DOENCAS TRANSMISSIVEIS
Année:
2004
Type de document:
Article
Pays d'affiliation:
Espagne