Demonstration of inhibitory guanine nucleotide regulatory protein (Gi) function in liver and hepatocyte membranes from streptozotocin-treated rats.
Biochem J
; 284 ( Pt 2): 301-4, 1992 Jun 01.
Article
de En
| MEDLINE
| ID: mdl-1534652
ABSTRACT
By using a defined plasma-membrane preparation, functional inhibition of adenylate cyclase activity by the inhibitory G-protein (Gi) was observed in liver and hepatocyte membranes from rats made diabetic by streptozotocin. These observations contrast with previous reports which have shown a defect in Gi in this diabetic animal model. These results suggest that Gi function is not impaired in the livers of streptozotocin-treated rats and that plasma-membrane preparation procedures should be clearly defined before ascribing Gi defects to a pathological state such as diabetes.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines G
/
Diabète expérimental
/
Foie
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Biochem J
Année:
1992
Type de document:
Article
Pays d'affiliation:
Royaume-Uni