Clinical and familial correlates of tardive dyskinesia in India and Israel.
J Postgrad Med
; 50(3): 167-72; discussion 172, 2004.
Article
de En
| MEDLINE
| ID: mdl-15377799
ABSTRACT
BACKGROUND:
Antipsychotic drugs are widely used for the treatment of psychosis, especially schizophrenia. Their long-term use can result at times in serious side-effects such as Tardive Dyskinesia (TD). Since over 80% of schizophrenia sufferers (lifetime prevalence 1%) receive long-term antipsychotic drug treatment, the extent of the problem is potentially large. Increasing age is the most consistently demonstrated risk factor for TD.AIMS:
To assess effect of different clinical factors and demographic variables in India and Israel and sib pair concordance of Tardive Dyskinesia (TD) in India. SETTINGS ANDDESIGN:
The study was conducted simultaneously among Indian and Israelisubjects:
ascertainment was family-based in India and hospital-based in Israel. METHODS ANDMATERIAL:
In India the instruments used were Diagnostic Interview for Genetic Studies (DIGS), Positive and Negative Syndrome Scale (PANSS), Abnormal Involuntary Movement Scale (AIMS), and Simpson Angus Scale (SAS). The last three instruments were also used in Israel. STATISTICALANALYSIS:
Regression analysis and Pearson's correlation. RESULTS ANDCONCLUSIONS:
TD symptoms were present in 40.4% of 151 Israeli subjects and 28.7% of 334 Indian subjects. While age at onset and total scores on PANSS were significant predictors of TD in both the samples, lower scores on the Global Assessment of Functioning Scale (GAF), diagnostic sub-group and male gender were significant predictors among Indians. There was no concordance of TD symptoms among 33 affected sib-pairs from India.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Neuroleptiques
/
Dyskinésie due aux médicaments
Type d'étude:
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
J Postgrad Med
Année:
2004
Type de document:
Article