Intraflagellar transport motors in Caenorhabditis elegans neurons.
Biochem Soc Trans
; 32(Pt 5): 682-4, 2004 Nov.
Article
de En
| MEDLINE
| ID: mdl-15493987
ABSTRACT
IFT (intraflagellar transport) assembles and maintains sensory cilia on the dendritic endings of chemosensory neurons within the nematode Caenorhabditis elegans. During IFT, macromolecular protein complexes called IFT particles (which carry ciliary precursors) are moved from the base of the sensory cilium to its distal tip by anterograde IFT motors (kinesin-II and Osm-3 kinesin) and back to the base by retrograde IFT-dynein [Rosenbaum and Witman (2002) Nat. Rev. Mol. Cell Biol. 3, 813-825; Scholey (2003) Annu. Rev. Cell Dev. Biol. 19, 423-443; and Snell, Pan and Wang (2004) Cell 117, 693-697]. In the present study, we describe the protein machinery of IFT in C. elegans, which we have analysed using time-lapse fluorescence microscopy of green fluorescent protein-fusion proteins in concert with ciliary mutants.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Neurones
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Biochem Soc Trans
Année:
2004
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique