Synthesis of 9-acridinyl sulfur derivatives: sulfides, sulfoxides and sulfones. Comparison of their activity on tumour cells.
Eur J Med Chem
; 39(12): 1029-38, 2004 Dec.
Article
de En
| MEDLINE
| ID: mdl-15571864
ABSTRACT
The synthesis of several acridine thioethers is described. These compounds were oxidized to give new sulfoxides and sulfones. Among 23 compounds prepared, 19 were tested in vitro against the human cancer cell lines panel of NCI screening. Activity is increased 5-10 times from sulfides to sulfoxides. Among substituted groups in the side chain, sulfur mustard, epoxy sulfide and sulfoxide displayed the most interesting activity.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sulfures
/
Sulfones
/
Sulfoxydes
/
Antinéoplasiques
Limites:
Humans
Langue:
En
Journal:
Eur J Med Chem
Année:
2004
Type de document:
Article
Pays d'affiliation:
France